It Was Him: The Many Murders of Ed Edwards centers on Wayne Wolfe who, less than a year ago, discovered that his real grandfather was the deceased killer Ed Edwards who was convicted of five cold cases in his 70s, but had potentially embarked on a decades-long murder spree. The series examines the infamous murderer through an investigation led by Wolfe and John Cameron, a cold-case expert and retired detective who has been investigating Edwards for almost a decade. Cameron's meticulously compiled evidence has Edwards as the ultimate suspect in some of the most well-known murder cases, including the Zodiac Killer, Laci Peterson and many more.