When a tormented scientist is murdered by radiation poisoning, Detectives Goren and Eames discover that the victim was working with Dr. Manotti a famous physicist in a wheelchair, on the controversial "Theory of Everything" - an unproven design that would re-configure the definition of the universe. Even as the police duo suspects the brainiac's beautiful and controlling trophy wife, they are curious about an approaching international conference in Berlin that would require Manotti to explain his theory - which would ensure his scientific immortality.