In Frankfurt, the mayor has a conflict with the garbage men reducing their salaries and their class is now on strike. The heat associated to the garbage bring rats to the city to search food. The helicopter pilot Frank Dabrock orders to cut the power to the city to save a little girl that is looking for her dog near to a powered electric cable and the Stock Exchange is affected by his act. Dabrock delivers the girl safe and sound to her mother Dr. Katrin but the mayor decides to punish him and transfer Dabrock to work in the rodent control department. Soon Katrin discovers that the rats are carrying a lethal virus and there is no vaccine to cure the humans bitten by them. Meanwhile Dabrock and his team learn that there are thousands of rats in the underground that need to be exterminated but the army has different opinion and quarantine Frankfurt.