An unsuccessful photojournalist, Nate Larchwood, tags along with his best friend and photographer, Sean Kissinger, to a quarantined island. The plan is to be the first to take photos of a fierce epidemic that has plagued the island population. The disease causes those infected to be permanently in a state of murderous fury; attacking all of those not infected. In order to get to the island, they need Ben Potter, an opportunist with motives of his own.