Unfriend narrates the story of 10 year old Aishu, a bubbly girl who loves everything about her life. Her neighbor and class mate Aravind is her best friend. Aishu’s hero is her brother, a plus two student, whom she adores and wants to be like him when she grows up. When she notices him smoking she thinks he is like the film heroes. One day Aravind finds her brooding and to his queries she reveals that her brother is sick, he takes injections every day, and she fears for his life. The childhood innocence and carefree nature is lost to Aishu when her brother indulges in abnormal behavioral patterns under the influence of drugs.