After a dinner with his closest colleagues, Professor Karl-Friedrich Boerne (Jan Josef Liefers) suffers a catastrophic car accident on his way to vacation. Seriously injured, he is taken to the hospital, where the doctors in the intensive care unit are fighting for his life. Chief Inspector Frank Thiel (Axel Prahl) is suspicious of the matter – his gut feeling tells him that something is wrong with Boerne's accident. Was it really attempted murder? Public prosecutor Wilhelmine Klemm (Mechthild Großmann) refers to the colleagues who are investigating the accident and forbids Thiel to conduct his own investigations, which of course does not prevent him from doing his own research. Meanwhile, Boerne's vacation replacement appears in forensic medicine - Dr.
Jens Jacoby (Hans Löw), a young, charismatic colleague who has just returned from Brazil. He quickly wins Silke "Alberich" Haller's (ChrisTine Ursprechen) sympathy, and together the two search for the truth at Thiel's side.