One day after his last visit to the family doctor, Olaf Mühlhaus died unexpectedly. The pensioner was terminally ill, but countless hematomas on the emaciated body of the corpse make the inspectors Till Ritter and Felix Stark doubt that the illness was the cause of the man's sudden death. When the autopsy revealed that it was not domestic violence but a medication error that led to the death of Olaf Mühlhaus, the doctor treating him, Dr. Gerhard Schmuckler and his group practice targeted by the Berlin investigators. Mühlhaus had been treated by Schmuckler for years – but on the day before his death, Antje Berger, the new doctor on the team, took care of the chronically ill patient.
While Ritter and Stark are looking for who is responsible for the deadly mistake, they are confronted with the excesses of the ailing healthcare system: expensive medicines with tight budgets, human fates like that of little Sophia Richthofen, whose mother Susanne is not only bitter about her daughter's severe cystic fibrosis , but also has to struggle with the high treatment costs.