The Medicine Game shares the remarkable journey of two brothers from the Onondaga Nation driven by a single goal; to beat the odds and play lacrosse for national powerhouse Syracuse University. The obstacles in their way are both frequent and daunting. In their darkest hour, and with their dreams crumbling around them, the boys must look to their family and to their Native teachings for guidance and stability. It is their search for identity that transitions The Medicine Game from a playful coming of age story, into an important study of modern Native American life. The film follows their story over the next six years as they struggle to rebuild their friendship, rescue a fading childhood dream, and gain a more resolute understanding of their identity and culture, both as athletes and the next generation of the Onondaga people.