Mystery Diagnosis is a television docudrama series that aired on OWN: Oprah Winfrey Network. Each episode focuses on two or more individuals who have struggled with obscure medical ailments, and their quest for a diagnosis. The program details the patients' and doctors' difficulty in pinpointing a diagnosis; often due to nonspecific symptoms, masquerading syndromes, the rarity of the condition or disease, or the patient's case being an unusual manifestation of said condition or disease. The series debuted on Discovery Health Channel in 2005, and was continued when the Oprah Winfrey Network replaced Discovery Health on January 1, 2011.