Dr. Gregory House and his team take medical cases only after everyone else has failed to diagnose a patient. A Kindergarten teacher begins speaking gibberish and passes out in front of her class. What looks like a possible brain tumor does not respond to treatment and provides many more questions than answers for House and his team as they engage in a risky trial-and-error approach to her case. When the young teacher refuses any additional variations of treatment and her life starts slipping away, House must act against his code of conduct and make a personal visit to his patient to convince her to trust him one last time.