Painkiller: The Tylenol Murders follows as investigators focus on a key suspect: James Lewis. In real-time, the five-part docuseries unravels the dark, complicated mystery of the crime, exploring the various police missteps and the madness that consumed Lewis, who lived in plain sight for more than 40 years. The series meticulously pieces together other crimes to which Lewis was connected, including extortion, dismemberment and another murder. Four decades later, the grieving families carry the horror of the heinous crime. Past clues and new technology raise the question: Could DNA evidence finally nail the killer?