The Three Gentlebros depicts a chaotic relationship between a strict and controlling mother and her three sons. Pimpattra, an overbearing mother plans to set up her three sons with the women she believes to be wife materials. But things are not going as Pimpattra has planned when three women who are far from her ideal daughter-in-law come into her sons' lives. Will these non-wifey types be able to win over this domineering mother? 

Pimpattra is a socialite who is successful in everything except her love life. She has been in many relationships. She has three sons who were born from different fathers. Itchaya, her oldest son, is a multiracial young businessman. Mom Luang Tewit or Thames, her second son, is an heir of a noble family which owns a well-known mall. Ashira, her youngest son, is a good-looking college student. Pimpattra is planning to find perfect wives for her sons to make up for her negligence while they were growing up. However, her sons don't seem to be happy about her plan. Her goal is also hindered by women in her sons' lives. Kaewklaw is a self-supporting woman whom Itchara is interested in. Nuengnaret is a sassy woman who is working with Thames but she is Pimpattra's foe. View Nareeya is a tough young woman whom Ashira hires to obstruct his mother's plan. What will be the endings of the three brothers' romance? How will their relationship with their mother wrap up?