A multi-generation comedy: Two late teens from a different kind of mixed marriage leave home to start their own lives. Their Father is a vampire, their mother is a witch, they are the worlds first hybrids, called Vampitch. The parents give chase because the children are in danger, but do not know. After failed attempts to force the children to return home, the estranged grandparents, who were against the mixed marriage in the first place, are summoned to help. The children using their new found hybrid powers stay one jump ahead of their family, and unknown to them, a group of vampire hunters.