In the eighties and nineties, as AIDS ravaged the United States gay community, the AIDS Memorial Quilt was born out of a public battle for treatment and understanding. The Last One is a feature-length documentary tracing its history as an international art project and the role it continues to play as a response to a disease that still imperils vulnerable communities around the world. Through the intensely personal stories of its founders, volunteers, and panel-makers, The Last One examines how stigma and discrimination exacerbated and still fuel a disease that has already claimed the lives of 30 million people and currently infects 65 million men, women and children around the globe—including 50,000 new infections a year in the US alone.