A man was murdered and left in a sexually humiliating situation. During the autopsy, he was diagnosed with knockout drops, which is unusual because most women are drugged and abused with knockout drops. A case that gets to Lena Odenthal's kidneys, especially since she herself is ailing: exhausted from the many cases she has already worked on; only because Kopper is the wedding musician for his cousin in Italy and it's stressful because Kopper's deputy, the young case analyst Johanna Stern, doesn't harmonize at all with Lena's way of working. Johanna is theory and expertise. Lena is practice and gut feeling. atIn their investigations, Lena Odenthal and Johanna Stern found out that there were also cases of young women who were raped with the help of knockout drops.
However, they can't remember anything. Stunned with these drops, young Betty is also caught wandering around. However, there is no evidence of abuse. Was she just lucky, or does her case have nothing to do with the other cases? Did one of the abused women seek revenge on the murder victim, or does his death have more to do with his family or professional situation? Lena Odenthal faces a difficult task.