Chief Inspector Nick Tschiller (Til Schweiger) and his colleague Yalcin Gümer (Fahri Ögün Yardim) put the Kurdish Astan clan under pressure, which threatens to take power in the Hamburg underworld in a bloody fight against the Bürsum clan. Although Firat Astan (Erdal Yildiz), against whom the mismatched couple investigated in the first case, is in prison, he puts a bounty on Nick's death. When Nick wants to drive his ex-wife Isabella (Stefanie Stappenbeck) to the airport, they both almost become victims of an assassination attempt. Nick Tschiller pulls itconsequences and insists that daughter Lenny (Luna Schweiger) move back in with her mother. Yalcin has his colleague declared dead for his own protection, but Nick unilaterally turns up at Firat Astan's prison to warn him of further attacks.
When Nick learns that the clan wants to get into the drug business and that a huge shipment of crystal meth is on its way to Hamburg, war between the gangsters breaks out openly. Together with Enno Kromer (Ralf Herforth), Nick gets the drug specialists of the LKA for help.