In the remote heights of the Transylvania Alps, Dracula awakes after a 100-year sleep. Dracula starts havoc by releasing a strange glowing powder that turns people into vampires. Meanwhile, Batman and Robin receive a distress call and speed off to Transylvania. They search Dracula's castle, only to get captured by Dracula himself. Later Wonder Woman and Aquaman arrive in Transylvania after the Wonder Twins report it was taken over by bats, only to be attacked by dozens of mindless vampires. Another report of vampire attacks was made and this time Superman went to Vienna to stop them. While in Vienna, Superman runs into Dracula, who was continuing his plans of conquest, and gets turned into a vampire. Realizing Superman is under Dracula's control, the Wonder Twins attempt to stop the victimized Man of Steel. Wonder Woman, Aquaman, Batman, and Robin all escape the face of danger, only to find that Superman and the Wonder Twins have been turned into vampires and are turning nearly everyone else into vampires as well. The four Super Friends regroup at the Biological Research Center in Switzerland to find a way to reverse the effects the vampires have on people. They now must find a strange breed of South American bat in the Andes Mountains whose cave has gases that could reverse the vampire effect. It is now up to the Super Friends to transform the vampires back to normal and figure out a way to stop Dracula.