In the distant future, the social outcast Derek Mullard watches a video of the world being destroyed by history's biggest villain - Danger Mouse! To make matters worse, Danger Mouse is Derek's ancient ancestor and the reason he's forbidden from marrying his beautiful paramour, Pennyfold. Meanwhile, in the present day, Danger Mouse is in the midst of foiling Quark's latest plot, which involves auctioning off the nice bits of the world and compact crushing the rest. A time-travelling Derek arrives on the scene to confront Danger Mouse and prevent the world's destruction, correcting the course of history in the process.