The Atlantis team encounters the Hoffans, a human civilization in the process of rebuilding their society since the last attack of the Wraith. The resilient Hoffans have developed the beginnings of a drug that could potentially make them immune to their enemies. Fearing that the next Wraith culling will come before they are able to complete their tests, the leaders demand that their people be inoculated before the drug can be proven safe. Dr. Beckett argues that there is no way to know what the true effects of the drug will be. Can Beckett make the Hoffans see reason, or has their haste made them blind to the epidemic they may be unleashing upon themselves?