Handler talks with fellow comedians (including Margaret Cho, Aasif Mandvi, and Michael McDonald) about racism and racial humor in the United States, visits a former plantation, and explores some of Los Angeles' ethnic neighborhoods with Loni Love. She speaks with Al Sharpton to talk about race and race relations, and meets with a group of people representing several civil rights organizations to talk about the boundaries of racial humor. She also speaks with Matthew Heimbach about the rise of white-nationalism.