A veteran Green Beret is forced by a cruel Sheriff and his deputies to flee into the mountains and wage an escalating one-man war against his pursuers.

Only a few years after the all-out guerrilla war in First Blood (1982), John Rambo's former commanding officer, Colonel Sam Trautman, pulls him out of jail, only to send him back to a place he swore never to return: the impenetrable jungles of Vietnam. Entrusted with the dangerous task of collecting evidence that American POWs are still being held captive, Rambo agrees to infiltrate the unknown zone, and before long, he finds himself double-crossed, marooned behind the enemy lines. Once, John fought for his country. Now, the government has left him for dead in a Soviet-infested land. Can Rambo fulfil his suicide mission? Will he deliver his lethal justice?

Rambo mounts a one-man mission to rescue his friend Colonel Trautman from the clutches of the formidable invading Soviet forces in Afghanistan.

In Thailand, John Rambo joins a group of mercenaries to venture into war-torn Burma, and rescue a group of Christian aid workers who were kidnapped by the ruthless local infantry unit.

Rambo must confront his past and unearth his ruthless combat skills to exact revenge in a final mission.